Expression levels of RhoA in bronchoalveolar lavage fluid of asthma patients allergic to dust mites / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1384-1386, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-268753
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of RhoA in the bronchoalveolar lavage fluid (BLF) from asthma patients allergic to dust mites and study its clinical significance.</p><p><b>METHODS</b>BLF was collected from 47 mite-allergic asthma patients, 15 asthma patients non-allergic to dust mites and 7 healthy volunteers to detect RhoA expression by immunohistochemistry.</p><p><b>RESULTS</b>The total positivity rates of RhoA expression were 66.7% in mite-allergic asthma patients, 70.2% in asthma patients non-allergic to dust mites and 0 in healthy volunteers, showing significant difference between the 3 groups (P<0.01). No statistical difference was observed in RhoA expression levels between male and female asthma patients allergic to dust mites (P>0.05). The total positivity rate was 83.3% in asthma children allergic to dust mites, higher than that in other patients with different ages, but their RhoA expression levels showed no significant differences (P>0.05). The total positive rates were 33.3%, 57.9%, 88.2% and 100.0% in patients with clinical grades I, II, III and IV, showing significant differences (P<0.05).</p><p><b>CONCLUSIONS</b>The positivity rate of RhoA in the BLF is higher in asthma patients allergic to dust mites than in normal healthy subjects, increases with the clinical grade.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Bronchoalveolar Lavage Fluid
/
Case-Control Studies
/
Chemistry
/
RhoA GTP-Binding Protein
/
Antigens, Dermatophagoides
/
Metabolism
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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