Expression of TMEM16A in gastric carcinoma and its clinical implications / 南方医科大学学报
Journal of Southern Medical University
;
(12): 794-797, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-268996
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications.</p><p><b>METHODS</b>A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.</p><p><b>RESULTS</b>TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).</p><p><b>CONCLUSION</b>Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
Carcinoma
/
Chloride Channels
/
Anoctamin-1
/
Metabolism
/
Neoplasm Proteins
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
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