Role of C5b-9 expression in skeletal muscle blood vessels in necrotizing myopathy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 714-717, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-269014
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of C5b-9 in the skeletal muscle blood vessels in patients with necrotizing myopathy and explore its role in the pathogenesis of this disease.</p><p><b>METHODS</b>The expression of C5b-9 and MHC-I in the skeletal muscular fibers and blood vessels in 4 patients with necrotizing myopathy was detected using enzymohistochemistry and immunohistochemistry.</p><p><b>RESULTS</b>Focal or dispersive necrotic muscle fibers with obvious phagocytosis were observed in all the 4 patients. No inflammatory cell infiltration was found in the perimysium or perivascular regions. HE staining showed a decreased number of local small blood vessels, and the some small blood vessels showed thickened vascular walls. Immunohistochemistry detected prominent C5b-9 expression in the necrotic muscle fibers and the blood vessels, and diffuse strong C5b-9 expression was found in the vascular walls, vascular endothelial cells and the smooth muscle layer. No MHC-I deposition was detected in the muscular fibers and blood vessels.</p><p><b>CONCLUSION</b>C5b-9 contributes to the pathogenesis of necrotizing myopathy mediated by pathologies in the blood vessels.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood
/
Complement Membrane Attack Complex
/
Muscle, Skeletal
/
Metabolism
/
Muscular Diseases
/
Necrosis
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
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