Exogenous 3', 5'-cyclic diguanylic acid prevents caries formation in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 639-642, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-269032
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of exogenous c-di-GMP in preventing dental caries formation in SD rats.</p><p><b>METHODS</b>Twenty-day-old SD rats with dental caries induced by S. Mutans infection were randomly divided into 3 groups for treatment with dental application of exogenous c-di-GMP, NaF solution or 0.9% NaCl, and changes in the bacterial number and scores of dental caries following the treatments were recorded.</p><p><b>RESULTS</b>Compared with 0.9% NaCl treatment, exogenous c-di-GMP treatment significantly lowered the scores of dental caries on the occlusal surface and smooth surface (P<0.05) but produced no obvious effect on the number of bacterial plagues (P>0.05).</p><p><b>CONCLUSION</b>Exogenous c-di-GMP can be a novel agent for prevention and treatment of tooth decay.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptococcus mutans
/
Cyclic GMP
/
Dental Caries
/
Therapeutic Uses
/
Disease Models, Animal
/
Microbiology
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
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