Expression of progesterone receptor membrane component-1 is associated with the malignant phenotypes of breast cancer / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the correlation of the expression of progesterone receptor membrane component-1 to the clinicopathological features of breast cancer.</p><p><b>METHODS</b>The expression of PGRMC1 was detected immunohistochemically in 60 surgical specimens of breast cancer, and the association of PGRMC1 with the histological grade, lymphatic metastasis, TNM stage and prognosis was assessed.</p><p><b>RESULTS</b>Positive CA-9 expression was detected in 37 (61.67%) of the cases. PGRMC1 expression was significantly correlated to lymph node metastasis (P=0.004), tumor size (P=0.03), TNM stage (P=0.039), overall survival rate (Log-rank=10.378, P=0.0001), and tumor-free survival (Log-rank=4.443, P=0.035), but not to the patients' age (P=0.196) or histological grade (P=0.526). Multivariate survival analysis indicated that PGRMC1 was an independent prognostic factor of breast cancer (P=0.002).</p><p><b>CONCLUSIONS</b>The expression of PGRMC1 is strongly associated with the progression of breast cancer, and may serve as a useful prognostic indicator of the malignancy.</p>