Study on the pharmacological mechanism of analgesic effect of injection stauntoniae / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 39-43, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-269043
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Injection Stauntoniae (IS) on voltage-gated sodium currents in dorsal root ganglion neurons and analyze its pharmacological mechanism of blocking the nerve conduction and anal gesic action.</p><p><b>METHODS</b>Whole-cell patch-clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons and the effects of 10% , 25% and 50 % IS on voltage-gated sodium currents were observed.</p><p><b>RESULTS</b>IS inhibited the peak sodium currents in dorsal root ganglion neurons in a dose-dependent way and affected the activation and inactivation process of the channels.</p><p><b>CONCLUSION</b>The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Sodium Channels
/
Ferns
/
Ganglia, Spinal
/
Analgesics
/
Injections
/
Metabolism
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2006
Type:
Article
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