Application of TC index location on Longa' s animal model of regional experimental cerebral ischemia and reperfusion / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the TC index location on a reform LONGA' s animal model of regional experimental cerebral ischemia and reperfusion.</p><p><b>METHODS</b>A total of 300 SD male rats were randomly divided into the pre-test group (n = 30), the original method group (n = 120, Longa' s method) and the reform method group [ n = 150, TC index location is defined by the length of rat incisor teeth root (T point) to the common carotid artery bifurcation (C point) ,the blood flow of a unilateral middle cerebral artery in the rats was reversibly blocked by the TC index location). The morphologic changes and the successful rate of the two methods to establish the rat model were compared.</p><p><b>RESULTS</b>The successful rate of TC index location modified model method was superior to that of original LONGA' s method,with significant difference in linear correlation analysis.</p><p><b>CONCLUSION</b>The reform LONGA' s animal model of regional experimental cerebral ischemia and reperfusion by the TC index location is a good method, and is worth applying in experimental study.</p>