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Allo-hematopoietic stem cell transplantation is a potential treatment for a patient with a combined disorder of hereditary spherocytosis / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 947-950, 2012.
Article in English | WPRIM | ID: wpr-269320
Responsible library: WPRO
ABSTRACT
Both human hereditary spherocytosis (HS) and chronic myelogenous leukemia (CML) are life threatening. Herein we have reported the case of a woman with a combined disorder of HS and CML who underwent the matched sibling allogeneic stem cell transplantation. The complete donor erythroid cells were obtained. The red blood cell counts significantly improved throughout life comparing with pre-hematopoietic stem cell transplantation (HSCT). Reticulocyte counts normalized, and BCR-ABL was cleared away. The total bilirubin level was also corrected in this recipient. Our case is a rare example with a combined disorder of HS and CML following allogeneic stem cell transplantation. HS was not a contraindication for patient in the matched sibling transplant setting.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Spherocytosis, Hereditary / Therapeutics / Transplantation, Homologous / Female / Humans / Hematopoietic Stem Cell Transplantation / Adult Type of study: Case report Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spherocytosis, Hereditary / Therapeutics / Transplantation, Homologous / Female / Humans / Hematopoietic Stem Cell Transplantation / Adult Type of study: Case report Language: English Journal: Chinese Medical Journal Year: 2012 Type: Article