Therapeutic effect of ketogenic diet for refractory epilepsy in children: a prospective observational study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 513-517, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-269441
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical efficiency, electroencephalogram (EEG) changes and cognitive improvements of ketogenic diet (KD) in children with refractory epilepsy.</p><p><b>METHODS</b>Twenty pediatric patients (7-61 months in age) with refractory epilepsy were recruited between August 2012 and August 2013. KD therapy was performed on all participants for at least 3 months based on a fasting initiation protocol with the lipid-to-nonlipid ratio being gradually increased to 4 1. Seizure frequency, type and degree were recorded before and during KD therapy. A 24 hours video-electroencephalogram (V-EEG) examination and Gesell Developmental Scale assessment were performed prior to KD therapy, and 3, 6, 9 months after KD therapy.</p><p><b>RESULTS</b>Six patients became seizure free after KD therapy, with a complete control rate of 30%. Seizure frequency reduction occurred in 13 (65%) patients, EEG improvement in 8 (40%) patients, and improvement in Gesell Developmental Scales (gross motor and adaptability in particular) in 6 (30%) patients. The KD therapy-related side effects were mild.</p><p><b>CONCLUSIONS</b>KD therapy is safety and effective in reducing seizure frequency and improving EEG and cognitive function in children with refractory epilepsy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Prospective Studies
/
Diet Therapy
/
Electroencephalography
/
Epilepsy
/
Diet, Ketogenic
Type of study:
Practice guideline
/
Observational study
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2014
Type:
Article
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