Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 242-247, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-269498
ABSTRACT
Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and peptic ulcer, but their pathogenesis is unclear. The role of gastric mucosal barrier dysfunction induced by impaired structure and function of tight junction in the pathogenesis of Hp-associated gastric diseases has received considerable attention in recent years. Tight junction is composed of a variety of proteins and molecules, including 3 integral membrane proteins (occludin, claudins, and junctional adhesion molecules) and a cytoplasmic protein (zonula occludens). This paper mainly describes the composition and function of various tight junction proteins, changes in tight junction protein function induced by Hp infection and their relationship with the incidence of gastric diseases, and the significance of enhancing the tight junction protein function in the prevention and treatment of Hp-associated gastric diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Stomach Diseases
/
Stomach Neoplasms
/
Virulence
/
Chemistry
/
Helicobacter pylori
/
Helicobacter Infections
/
Oxidative Stress
/
Tight Junction Proteins
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2014
Type:
Article
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