Survey of the evolutionary characteristics of influenza H1N1 hemagglutinin gene HA1 in 2000-2009 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 92-95, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-269619
ABSTRACT
<p><b>OBJECTIVE</b>To study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting different species during 2000-2009.</p><p><b>METHODS</b>The target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree.</p><p><b>RESULTS</b>The HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus.</p><p><b>CONCLUSION</b>The HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Virology
/
Antigenic Variation
/
China
/
Epidemiology
/
Hemagglutinin Glycoproteins, Influenza Virus
/
Computational Biology
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
Genes, Viral
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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