Establishment of a goat model of tibial bone hole defect suitable for repair using injectable bone materials / 南方医科大学学报
Journal of Southern Medical University
;
(12): 35-37, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-269633
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a goat model of tibial bone hole defect suitable for studies of bone defect repair using tissue-engineered injectable bone materials.</p><p><b>METHODS</b>A circular hole bone defect 1.2 cm in diameter was induced below the tibial medial plateau of the goat. X-ray, histological inspection, and image analysis were carried out to evaluate the validity of the model in simulating limb bone defect for the study of tissue-engineered injectable bone materials.</p><p><b>RESULTS</b>At 4 and 8 weeks after the operation, neither X-ray nor histological examination showed obvious bone tissues in the bone defect. Image analysis showed a area of new bone tissue formation of (8.79 - or + 3.63)% in the total defect area at 4 weeks, which increased to (15.41 - or + 4.21)% at 8 weeks.</p><p><b>CONCLUSION</b>The goat model of tibial bone hole defect established in this study is suitable for studying the ability of injectable bone materials for repairing limb bone defect, and offers a simple and reliable means to simulate the local condition of bone regeneration and mechanical environment of bone defect in the limbs.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Tibia
/
Tibial Fractures
/
Wounds and Injuries
/
Biocompatible Materials
/
Bone Regeneration
/
Goats
/
Bone Substitutes
/
Tissue Engineering
/
Disease Models, Animal
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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