Investigation of basement membrane proteins in a case of granular cell ameloblastoma / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 45-49, 2012.
Article
in English
| WPRIM
| ID: wpr-269651
ABSTRACT
Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Basement Membrane
/
Ameloblastoma
/
Mandibular Neoplasms
/
Cell Adhesion Molecules
/
Keratinocytes
/
Chemistry
/
Fibronectins
/
Laminin
/
Collagen Type IV
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
International Journal of Oral Science
Year:
2012
Type:
Article
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