DNA repair and synthetic lethality / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 176-179, 2011.
Article
in English
| WPRIM
| ID: wpr-269661
ABSTRACT
Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach, which may lead to new therapeutic strategies. It is well known that poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitors show the synthetically lethal effect in tumors defective in BRCA1 or BRCA2 genes encoded proteins that are required for efficient HR. In this review, we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Recombination, Genetic
/
Breast Neoplasms
/
Gene Expression Regulation, Neoplastic
/
Genes, Tumor Suppressor
/
Mutagenesis
/
Genes, cdc
/
DNA Repair
/
Rad52 DNA Repair and Recombination Protein
/
Poly(ADP-ribose) Polymerase Inhibitors
Limits:
Animals
/
Humans
Language:
English
Journal:
International Journal of Oral Science
Year:
2011
Type:
Article
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