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Effect of changji' an oral liquid on activated signal alterative intensity in algesthesia domain in patients with diarrhea type irritable bowel syndrome due to gan-pi disharmony / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 967-970, 2005.
Article in Chinese | WPRIM | ID: wpr-269855
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Changji' an (CJA) oral liquid on the activated signal alterative intensity (ASAI) in intracranial algesthesia domain in patients with diarrhea type irritable bowel syndrome (IBS) due to Gan-Pi disharmony.</p><p><b>METHODS</b>Twenty-four patients were randomly divided into 2 groups, 14 in the treated group and 10 in the control group, they were administrated with CJA and placebo respectively. The sensory threshold and score in the two groups recorded by rectal inflation test were compared and analyzed. The change of ASAI in intracranial algesthesia domain was analyzed by functional magnetic resonance imagine (fM-RI) during rectum being inflated with 30 ml, 60 ml, 90 ml and 120 ml of gas respectively.</p><p><b>RESULTS</b>The initial sensory thresholds in the two groups were insignificantly different, but significant difference did show between the two groups in urgent defecation threshold and pain threshold after treatment (P < 0.05). Comparison in visual simulative scores between the two groups after treatment at rectal inflated for 30 ml showed no significant difference, but it showed significant difference when the inflation was over 30 ml (P < 0.05). In the treated group, the ASAI in insula cortex when rectal inflation being 90 ml or 120 ml and that in thalamus when rectal inflation being 120 ml were significantly decreased (P < 0.05). But in the control group, it changed insignificantly after treatment.</p><p><b>CONCLUSION</b>The treatment of CJA on Gan-Pi disharmony caused diarrhea type IBS might be effected by regulating the ASAI in intracranial insula cortex and thalamus.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sensory Thresholds / Brain / Drugs, Chinese Herbal / Signal Transduction / Pain Threshold / Irritable Bowel Syndrome / Therapeutic Uses / Diagnosis, Differential / Diarrhea / Drug Therapy Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sensory Thresholds / Brain / Drugs, Chinese Herbal / Signal Transduction / Pain Threshold / Irritable Bowel Syndrome / Therapeutic Uses / Diagnosis, Differential / Diarrhea / Drug Therapy Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article