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Progress of study on brain protective effect and mechanism of Polygonum multiflorum / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 955-959, 2005.
Article in Chinese | WPRIM | ID: wpr-269857
ABSTRACT
This paper reviews the brain protective effect and mechanism of Polygonum multiflorum (PM), its extracts and active component, tetrahydroxystilbene-glucoside (2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside) published in recent decade. They have major effects as calcium channel antagonists, antioxidant, cholinomimetic drugs and cholinesterase inhibitors, as well as actions in regulating cell apoptosis and prolonging the ageing. The brain protective mechanism of PM is multi-target, multi-link and multi-way. Therefore, PM has great applicative value in prevention and treatment of senile neuropathies, such as Alzheimer's disease, Parkinson's disease and vascular dementia, etc.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Stilbenes / Drugs, Chinese Herbal / Plant Extracts / Calcium Channel Blockers / Chemistry / Neuroprotective Agents / Polygonum / Drug Therapy / Glucosides Limits: Animals / Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Stilbenes / Drugs, Chinese Herbal / Plant Extracts / Calcium Channel Blockers / Chemistry / Neuroprotective Agents / Polygonum / Drug Therapy / Glucosides Limits: Animals / Humans Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article