Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1198-1201, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-270176
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Tongluo Recipe on the expression of collagen IV (Col IV), fibronectin (FN), laminin (LN), transforming growth factor-beta1 (TGF-beta1) in rat renal tissues and explore the mechanism underlying these effects in rats with glomerular sclerosis.</p><p><b>METHODS</b>The pathological changes in the renal tissues of rats with glomerular sclerosis were observed microscopically, and the expressions of Col IV, FN, LN, and TGF-beta1 were detected using immunohistochemical staining and image analysis system.</p><p><b>RESULTS</b>Tongluo Recipe significantly decreased the expressions of Col IV, FN, LN and TGF-beta1 in the renal tissue of rats with glomerular sclerosis (P<0.05 or P<0.01) and obviously alleviated the renal pathologies (P<0.01).</p><p><b>CONCLUSION</b>The therapeutic effects of Tongluo Recipe are probably mediated by lowered expressions of Col IV, FN, LN and TGF-beta1.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Drugs, Chinese Herbal
/
Glomerulosclerosis, Focal Segmental
/
Random Allocation
/
Fibronectins
/
Treatment Outcome
/
Rats, Sprague-Dawley
/
Collagen Type IV
/
Therapeutic Uses
/
Drug Therapy
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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