Immunological activity of Streptomyces polysaccharide in normal and immunosuppressed mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the immunological activity of Streptomyces polysaccharide (SMP) on normal and immunosuppressed mice.</p><p><b>METHODS</b>The effect of SMP on the proliferating activity of normal mouse splenocytes was tested in the mixed lymphocyte culture, and the changes of peripheral blood T lymphocytes were evaluated with acid a-naphthyl acetate esterase (ANAE) method. The ratio of Lyt2+ and L3T4+ T cell subsets was measured by flow cytometry.</p><p><b>RESULTS</b>SMP stimulated obvious proliferation of mixed lymphocytes, showed protective effects on T lymphocyte and increased the ratio of Lyt2+ and L3T4+ cell subsets to nearly normal level in immunosuppressed mice.</p><p><b>CONCLUSIONS</b>SMP can regulate the immune function in mice.</p>