Relationship between anti-myelin basic protein antibody and myelinoclasis in rat brain stem after brain trauma / 南方医科大学学报
Journal of Southern Medical University
; (12): 1028-1030, 2008.
Article
in Zh
| WPRIM
| ID: wpr-270218
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relations between anti-myelin basic protein antibody (anti-MBP) variation and myelinoclasis in the brain stem following brain trauma.</p><p><b>METHODS</b>In rat models of brain trauma, MBP content and anti-MBP titer in the blood were measured using enzyme-linked immunosorbent assay (ELISA) at different time points after brain trauma, and the degree of myelinoclasis in the brain stem slices was assessed with osmic acid staining.</p><p><b>RESULTS</b>Early after brain trauma, MBP content in the blood increased followed by significant reduction 10 days later. Four days after the trauma, anti-MBP titer was markedly increased, accompanied by obvious exacerbation of myelinoclasis in the brain stem, both reaching the highest levels on day 10, at the point of which anti-MBP titer increased by 4 folds and the number of myelinoclasis by 10 folds compared with the control group. Anti-MBP titer and brain stem myelinolysis both lowered 30 days later. Correlation analysis showed an intimate positive correlation between anti-MBP titer and the degree of myelinoclasis.</p><p><b>CONCLUSION</b>After brain trauma, MBP is released as a specific antigen into the blood to stimulate the immune system for anti-MBP production, and the antibody is intimately related to the brain stem myelinoclasis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Transcription Factors
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Blood
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Brain Injuries
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Brain Stem
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Random Allocation
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Rats, Sprague-Dawley
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Demyelinating Autoimmune Diseases, CNS
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Myelin Basic Protein
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Allergy and Immunology
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article