Biocompatibility of polyurethane-BaFe(12)O(19 ) composite microsphere as a new endovascular embolization material / 南方医科大学学报
Journal of Southern Medical University
; (12): 1002-1004, 2008.
Article
in Zh
| WPRIM
| ID: wpr-270226
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the biocompatibility of polyurethane-BaFe(12)O(19) magnetic composite microsphere as a new endovascular embolization material.</p><p><b>METHODS</b>The biocompatibility of BaFe(12)O(19) particle was evaluated in vitro using Ames test, cell toxicity test, acute and subacute systemic toxicity test, hemolysis test, bleeding time and clotting time test and blood clotting function assay.</p><p><b>RESULTS</b>Ames test showed that the MR values of this particle leaching solution were all less than 2 without mutagenicity. Cell toxicity test showed that leaching solution at different concentrations had grade I toxicity on L929 cells. Acute and subacute systemic toxicity test showed that the experimental animals had good general condition without obvious pathological abnormality. The hemolysis rate of experimental group was 2.43%, which met the ISO standard (no more than 5%). The bleeding time and clotting time in mice were comparable between the experimental group and control group (P>0.05). There were no significant differences in blood clotting function between experimental group and control group (P>0.05).</p><p><b>CONCLUSION</b>The material has no obvious toxicity or mutagenicity, and does not cause hemolysis or hemopexis or affect the bleeding time and clotting time. Polyurethane-BaFe(12)O( 19) particle possesses satisfactory biocompatibility.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polyurethanes
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Biocompatible Materials
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Ferric Compounds
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Chemistry
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Barium Compounds
/
Toxicity Tests
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Cell Line, Tumor
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Embolization, Therapeutic
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Toxicity
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Microspheres
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article