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Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits / 中华创伤杂志(英文版)
Chinese Journal of Traumatology ; (6): 242-244, 2003.
Article in English | WPRIM | ID: wpr-270322
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of recombinant human basic fibroblast growth factor (rhbFGF) on angiogenesis during mandible fracture healing in rabbit.</p><p><b>METHODS</b>Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor VIII related antigen (F8-RA) in callus was examined with immunohistochemical staining.</p><p><b>RESULTS</b>The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P<0.01).</p><p><b>CONCLUSIONS</b>The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Recombinant Proteins / Fibroblast Growth Factor 2 / Fracture Healing / Neovascularization, Physiologic / Mandibular Fractures Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese Journal of Traumatology Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Recombinant Proteins / Fibroblast Growth Factor 2 / Fracture Healing / Neovascularization, Physiologic / Mandibular Fractures Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese Journal of Traumatology Year: 2003 Type: Article