Changes in urotensin-II expression in airway remodelling in asthmatic rats / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 287-289, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-270362
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of urotension-II in serum and bronchoalveolar lavage fluid (BALF) in the process of airway remodelling in asthmatic rats.</p><p><b>METHODS</b>Thirty-two male Sprague-Dawley (SD) rats were randomly divided into normal control and 2-week, 4-week and 8-week asthmatic groups (OVA inhalation of 2, 4 and 8 weeks respectively). Rats were sensitized and challenged by OVA to establish a model of asthma. The bronchial wall thickness and the airway smooth muscle thickness were measured by image analysis system. The urotension-II contents in serum and BALF were determined using ELISA.</p><p><b>RESULTS</b>The bronchial wall thickness and the airway smooth muscle thickness in the three asthmatic groups significantly increased compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the three asthmatic groups also increased significantly compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the 8-week asthmatic group were the highest, followed by the 4-week and the 2-week asthmatic groups (P<0.01). BALF urotension-II contents were positively correlated with the bronchial wall thickness and the airway smooth muscle thickness as well as serum U-II contents in the four groups.</p><p><b>CONCLUSIONS</b>The urotension-II contents in serum and BALF in the process of airway remodeling increase in asthmatic rats. The changes in serum and BALF urotension-II contents may be associated with airway remodeling in asthmatic rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Asthma
/
Urotensins
/
Blood
/
Bronchi
/
Bronchoalveolar Lavage Fluid
/
Chemistry
/
Rats, Sprague-Dawley
/
Airway Remodeling
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Type:
Article
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