Serum levels of IL-13 and TNF-alpha in children with Mycoplasma pneumoniae pneumonia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 275-277, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-270366
ABSTRACT
<p><b>OBJECTIVE</b>To examine serum levels of interleukin-13 (IL-13) and tumor necrosis factor alpha (TNF-alpha) in children with Mycoplasma pneumoniae (MP) pneumonia.</p><p><b>METHODS</b>Eighty children with MP pneumonia complicated by wheezing or without (n=40 each), 40 children with pneumonia from non-MP infection and 40 healthy children were enrolled. Serum levels of IL-13 and TNF-alpha were measured using ELISA.</p><p><b>RESULTS</b>The serum levels of IL-13 and TNF-alpha in the MP pneumonia group were significantly higher than those in non-MP pneumonia group and the healthy control group (P<0.01). The children with MP pneumonia complicated by wheezing had increased serum levels of IL-13 (214.6 + or - 67.2 ng/L vs 189.6 + or - 52.1 ng/L; P<0.01) and TNF-alpha(0.55 + or - 0.13 ng/mL vs 0.42 + or - 0.16 ng/mL; P<0.01)compared with those without wheezing.</p><p><b>CONCLUSIONS</b>The increase in serum levels of IL-13 and TNF-alpha may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia, Mycoplasma
/
Blood
/
Respiratory Sounds
/
Tumor Necrosis Factor-alpha
/
Pneumonia, Bacterial
/
Interleukin-13
/
Allergy and Immunology
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Type:
Article
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