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Relationship between gene polymorphisms in MMP-9 and Helicobacter pylori-related upper gastrointestinal disease in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 262-266, 2010.
Article in Chinese | WPRIM | ID: wpr-270369
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of the promoter of matrix metalloproteinase-9 (MMP-9) gene polymorphisms with the susceptibility and clinical features of Helicobacter pylori (H. pylori)-related chronic gastritis and duodenal ulcer in children.</p><p><b>METHODS</b>One hundred children with chronic gastritis, 32 children with duodenal ulcer and 102 healthy children were enrolled.The promoter of MMP-9-1562C/T gene polymorphisms were genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and sequencing. MMP-9 mRNA expression in gastric mucosa was confirmed by reverse transcription polymerase chain reaction.</p><p><b>RESULTS</b>The genotype distributions and allele frequencies of MMP-9-1562C/T gene polymorphisms were similar in gastric upper gastrointestinal disease and healthy subjects. The relative risk for H.pylori infection in C/C genetype carriers was 3.1 times as high as that in T allele (C/T+T/T) carriers in children with chronic gastritis. MMP-9-1562 C/T gene polymorphisms did not affect MMP-9 mRNA expression level.</p><p><b>CONCLUSIONS</b>These data suggest that MMP-9-1562 C/T gene polymorphisms are not associated with susceptibility to chronic gastritis and duodenal ulcer in children. The C/C genotype of MMP-9-1562 C/T gene polymorphism might be associated with H.pylori infection.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Chronic Disease / Helicobacter pylori / Helicobacter Infections / Matrix Metalloproteinase 9 / Duodenal Ulcer / Gastritis / Genetics / Genotype Type of study: Etiology study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Chronic Disease / Helicobacter pylori / Helicobacter Infections / Matrix Metalloproteinase 9 / Duodenal Ulcer / Gastritis / Genetics / Genotype Type of study: Etiology study Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2010 Type: Article