Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 113-116, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-270416
ABSTRACT
<p><b>OBJECTIVE</b>To study the value of eosinophils (EOS) and interleukin-17 (IL-17) in nasopharyngeal secretions in the evaluation of progress of wheezing in children under 5 years old.</p><p><b>METHODS</b>Fifty-three children under five years old who had recurrent wheezing were classified into two groups wheezing group I with atopic body (n=27) and wheezing group II without atopic body (n=26). Twenty pre-surgical children with non-infectious disease were used as the control group. Nasopharyngeal secretions were collected. Inflammatory cells in nasopharyngeal secretions were counted under the microscope. IL-17 levels in supernatants were measured using ELISA.</p><p><b>RESULTS</b>EOS counts in nasopharyngeal secretions in wheezing group I were significantly higher than those in wheezing group II and the control group (p<0.05, p<0.01, respectively). There were no significant differences in EOS counts between wheezing II and the control groups. The IL-17 levels in both wheezing groups were significantly higher than those in the control group (p<0.01), and the wheezing group I had increased IL-17 levels than wheezing group II (1 474+/-974 pg/mL vs 788+/-132 pg/mL; p<0.05). The IL-17 level was positively correlated with the EOS counts in wheezing group I (r=0.62, p<0.05).</p><p><b>CONCLUSIONS</b>EOS counts and IL-17 levels in nasopharyngeal secretions may be used as indices for identifying the tendency to develop asthma in children under 5 years old with wheezing.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Respiratory Sounds
/
Nasopharynx
/
Bodily Secretions
/
Interleukin-17
/
Allergy and Immunology
/
Eosinophils
/
Leukocyte Count
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Type:
Article
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