The Prevalence of HIV Drug Resistance among Treatment-failure Individuals and Treatment-naïve Individuals in China: A Meta-analysis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 858-871, 2014.
Article
in English
| WPRIM
| ID: wpr-270529
ABSTRACT
<p><b>OBJECTIVE</b>To understand drug resistance prevalence among treatment-failure and treatment-naïve HIV-positive individuals in China.</p><p><b>METHODS</b>We searched five electronic databases (Wanfang, CNKI, CQVIP, SinoMed, and Pubmed) for studies of HIV drug resistance. Random-effects models were carried out to estimate the prevalence of drug resistance among treatment-failure and treatment-naïve individuals, respectively.</p><p><b>RESULTS</b>The estimated nationwide rates of HIV drug resistance to any-class drugs among treatment-failure and treatment-naïve individuals were 57% (95% CI 49%-65%) and 3.23% (95% CI 2.47%-4.07%), respectively. Among the drug classes, the prevalence of resistance to PIs was low (1.45%; 95% CI 0.73%-2.33%) in treatment-failure individuals, although high rates of resistance to NNRTIs (54%; 95% CI 45%-63%) and NRTIs (40%; 95% CI 32%-49%) were found. Resistance to any-class drugs, NNRTIs and NRTIs manifested regional differences, but resistance to PIs did not. Positive correlations were observed between resistance to NNRTIs and NRTIs among treatment-failure and treatment-naïve individuals, respectively.</p><p><b>CONCLUSION</b>The prevalence of HIV drug resistance to NNRTIs and NRTIs among treatment-failure individuals was high. In contrast, the prevalence of drug resistance among treatment-naïve individuals was low. The epidemics of drug resistance matched current treatment strategies and interventions in China. Surveillance for HIV drug resistance is necessary to assess the sustainability and durability of current treatment regimens.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
HIV Infections
/
Randomized Controlled Trials as Topic
/
China
/
Epidemiology
/
Prevalence
/
Treatment Failure
/
Anti-HIV Agents
/
Drug Resistance, Viral
/
Therapeutic Uses
Type of study:
Controlled clinical trial
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article
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