Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 462-465, 2014.
Article
in English
| WPRIM
| ID: wpr-270580
ABSTRACT
Parkinson's disease (PD) is a typical degenerative disease, which is characterized by the most obvious symptoms of movement dysfunction, including shaking, rigidity, slowness of movement and difficulty in walking and gait. This disease can not be clearly identified through laboratory tests at present, thus application of high-throughput technique in studying the expression profiles of PD helps to find the genetic markers for its early diagnosis. Studies on expression profiles of neurodegenerative diseases have revealed the novel genes and pathways involved in the progress of illness. In this study, the expression profiles of PD in blood were compared, showing that 181 differentially expressed genes (DEG) exhibit a similar expression trend both in patients and in normal controls. These genes are enriched significantly in some biological processes, including development, response to drugs, and DNA-dependent regulation of transcription, etc, highlighting that the genetic markers can be used in early diagnosis of PD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Blood
/
Biomarkers
/
Genetic Markers
/
Case-Control Studies
/
Mass Screening
/
Computational Biology
/
Gene Expression Profiling
/
Early Diagnosis
/
Diagnosis
Type of study:
Diagnostic study
/
Observational study
/
Screening study
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article
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