Application of gas chromatography-mass spectrometry in analyzing pharmacokinetics and distribution of deltamethrin in miniature pig tissues / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 426-435, 2014.
Article
in English
| WPRIM
| ID: wpr-270584
ABSTRACT
<p><b>OBJECTIVE</b>To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).</p><p><b>METHODS</b>Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.</p><p><b>RESULTS</b>The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330 ± 316.987 ng h/mL and 17.861 ± 11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004 ± 3.131 h.</p><p><b>CONCLUSION</b>The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrethrins
/
Swine
/
Swine, Miniature
/
Pharmacokinetics
/
Tissue Distribution
/
Models, Animal
/
Absorption
/
Gas Chromatography-Mass Spectrometry
/
Nitriles
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article
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