The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 212-214, 2014.
Article
in English
| WPRIM
| ID: wpr-270612
ABSTRACT
The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated. After K562 cells were treated with hydroquinone for 24 h, and hemin was later added to induce erythroid differentiation for 48 h, hydroquinone inhibited hemin-induced hemoglobin synthesis and mRNA expression of γ-globin in K562 cells in a concentration-dependent manner. The 24-h exposure to hydroquinone also caused a concentration-dependent increase at an intracellular ROS level, while the presence of N- acetyl-L-cysteine prevented hydroquinone- induced ROS production in K562 cells. The presence of N-acetyl-L-cysteine also prevented hydroquinone inhibiting hemin-induced hemoglobin synthesis and mRNA expression of γ-globin in K562 cells. These evidences indicated that ROS production played a role in hydroquinone-induced inhibition of erythroid differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Acetylcysteine
/
Cell Differentiation
/
Reactive Oxygen Species
/
K562 Cells
/
Dose-Response Relationship, Drug
/
Gamma-Globins
/
Genetics
/
Hemin
/
Hydroquinones
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article
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