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AduoLa Fuzhenglin down-regulates microwave-induced expression of β1-adrenergic receptor and muscarinic type 2 acetylcholine receptor in myocardial cells of rats / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 204-207, 2014.
Article in English | WPRIM | ID: wpr-270614
ABSTRACT
This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is down-regulated in myocardial cells of rats exposed to microwave radiation. ADL can protect rats against microwave-induced heart tissue injury.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Down-Regulation / Rats, Wistar / Receptors, Adrenergic, beta-1 / Protective Agents / Cell Biology / Receptor, Muscarinic M2 / Heart / Metabolism Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Down-Regulation / Rats, Wistar / Receptors, Adrenergic, beta-1 / Protective Agents / Cell Biology / Receptor, Muscarinic M2 / Heart / Metabolism Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2014 Type: Article