Expression and clinical significance of Endostatin, vascular endothelial growth factor and fibroblast growth factor basic-2 in laryngeal carcinoma / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
; (12): 687-691, 2007.
Article
in Zh
| WPRIM
| ID: wpr-270729
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the expression and clinical significance of Endostatin, vascular endothelial growth factor (VEGF) and fibroblast growth factor basic-2 (FGF-2) in the laryngeal squamous cell carcinoma (LSCC).</p><p><b>METHODS</b>The expression of Endostatin, VEGF and FGF-2 in 50 specimens of LSCC, 40 specimens of para-carcinoma and 10 specimens of normal laryngeal tissues were examined by Flow cytometry.</p><p><b>RESULTS</b>Compared with para-carcinoma and normal laryngeal tissues, the expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were different in statistics (P < 0.05); the expression level and positive rate of endostatin, VEGF, FGF-2 in LSCC are obviously higher than those in para-carcinoma and normal laryngeal tissues. The expression level and positive rate of Endostatin, VEGF, FGF-2 were no difference in statistics between para-carcinoma and normal laryngeal tissues (P > 0.05). The expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were associated with lymphoid metastasis and clinical stage, not associated with age, sex and clinical group.</p><p><b>CONCLUSIONS</b>Endostatin, VEGF and FGF-2 play important role in the incidence, development and prognosis of the LSCC.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
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Carcinoma, Squamous Cell
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Gene Expression Regulation, Neoplastic
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Laryngeal Neoplasms
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Fibroblast Growth Factor 2
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Endostatins
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Vascular Endothelial Growth Factor A
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Metabolism
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Neoplasm Staging
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2007
Type:
Article