Expression of monocyte chemotactic protein 1 and vascular endothelial growth factor in nasal polyps / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 508-510, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-270782
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between the expression of monocyte chemotactic protein 1 (MCP-1) and vascular endothelial growth factor (VEGF) in nasal polyp (NP) tissues and the role of MCP-1 in the formation of nasal polyps.</p><p><b>METHODS</b>Forty nasal polyp tissues obtained from NP patients were used to detect the expression of MCP-1 and VEGF at the levels of protein and mRNA by immunohistochemical and in situ hybridization assay. Twenty-five inferior turbinate (IT) samples obtained from chronic rhinitis patients were used as control.</p><p><b>RESULTS</b>The expression of MCP-1 and VEGF was higher in NP tissue than in IT at protein and mRNA levels (P <0.01). The expression of these two cytokines was positively correlated(r = 0.871, P <0.05).</p><p><b>CONCLUSIONS</b>MCP-1 and VEGF were involved in the formation of nasal polyps.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Nasal Polyps
/
Chemokine CCL2
/
Vascular Endothelial Growth Factor A
/
Metabolism
/
Nasal Mucosa
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2007
Type:
Article
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