Plasma transforming growth factor-beta1 levels in patients with erectile dysfunction / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 349-353, 2004.
Article
in English
| WPRIM
| ID: wpr-270885
ABSTRACT
<p><b>AIM</b>To evaluate the plasma TGF-beta1 level in erectile dysfunction (ED) patients of various causes.</p><p><b>METHODS</b>Sixty-two patients with ED and 26 potent men were subjected to the study. Based on multidisciplinary work-ups, including medical history, physical examinations, blood tests with lipid profile and hormones, penile duplex Doppler ultrasonogram and neurophysiological tests, causes for ED were classified as psychogenic (n=15), neurogenic (n=16) and vasculogenic (n=31). The plasma TGF-beta1 level was measured by the ELISA method.</p><p><b>RESULTS</b>The plasma TGF-beta1 level was significantly increased in the ED group (6.7+/-4.9 ng/mL), compared to the control (4.0 +/-2.1 ng/mL) (P<0.01). In the ED groups, there was a significant increase in the vasculogenic group (9.0 +/-5.5 ng/mL), compared to the psychogenic (3.8 +/-1.8 ng/mL) and neurogenic groups (4.8+/-3.2 ng/mL) (P<0.01). Of the vascular risk factors, both the smoking (7.5 +/-4.7 ng/mL) and dyslipidemia groups (7.4+/-4.4 ng/mL) showed significantly increased plasma TGF-beta1 levels, compared to the non-smokers (5.5+/-2.8 ng/mL), and those without dyslipidemia (4.8+/-2.8 ng/mL) (P<0.05).</p><p><b>CONCLUSION</b>Vascular risk factors are associated with an elevated plasma TGF-beta1 level, which may contribute to cavernous fibrosis and ED.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penis
/
Arteriosclerosis
/
Psychology
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Diagnostic Imaging
/
Smoking
/
Risk Factors
/
Transforming Growth Factor beta
/
Ultrasonography
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2004
Type:
Article
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