Androgenic effect of Mondia whitei roots in male rats / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 269-272, 2004.
Article
in English
| WPRIM
| ID: wpr-270896
ABSTRACT
<p><b>AIM</b>To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats.</p><p><b>METHODS</b>Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1, 2, 4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h. Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each Groups 1, 2 and 3 were given orally the plant extract (400 mg.kg(-1).day(-1)) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17 beta-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined.</p><p><b>RESULTS</b>In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P < 0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17beta -estradiol and the fertility compared to the controls.</p><p><b>CONCLUSION</b>Mondia whitei root extract possesses an androgenic property.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Pharmacology
/
Sperm Count
/
Testis
/
Testosterone
/
Blood
/
Plant Extracts
/
Rats, Wistar
/
Plant Roots
/
Gentiana
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2004
Type:
Article
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