Dual effect of angiopoietin-2 on angiogenesis in gastric cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 161-164, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-271028
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of Ang-2 on angiogenesis in gastric cancer.</p><p><b>METHODS</b>The expression of Ang-2 mRNA was analyzed by RT-PCR and the expression of VEGF and CD34 was detected by immunohistochemistry in 36 cases of gastric cancer tissues and their paired adjacent gastric mucosa.</p><p><b>RESULTS</b>The expression of Ang-2 mRNA was found both in gastric cancer and their paired adjacent gastric mucosa; the correlationship between the general expression levels of Ang-2 mRNA and microvessel density (MVD) in gastric cancer tissues was not found. However, in 27 cases whose Ang-2 mRNA expression levels in cancer tissues were lower than those in adjacent gastric mucosa. A significant positive correlation between the expression level of Ang-2 mRNA and MVD in the tumor tissues was found (r = 0.411, P < 0.05). In these 27 cases, the MVD in the gastric cancer tissues with positive VEGF expression (45.45 +/- 10.30) was higher than that with negative VEGF expression (30.15 +/- 8.69, P < 0.05), whereas in the other 9 cases whose expression levels of Ang-2 mRNA in cancer tissues were higher than those in adjacent gastric mucosa, a significant negative correlation between expression level of Ang-2 mRNA and MVD in the tumor tissues (r = -0.758, P < 0.05), but without correlation between the MVD and VEGF.</p><p><b>CONCLUSION</b>Under the conditions that the expression of Ang-2 mRNA in cancer tissues was lower than that in adjacent gastric mucosa, VEGF could promote the sprouting of new vessels along with Ang-2 upregulation. But under the conditions that the expression of Ang-2 mRNA in cancer tissues was higher than that in adjacent gastric mucosa, Ang-2 inhibited angiogenesis. Angiopoietin-2 may play a dual effect on angiogenesis in gastric cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Stomach Neoplasms
/
RNA, Messenger
/
Immunohistochemistry
/
Angiopoietin-2
/
Vascular Endothelial Growth Factor A
/
Gastric Mucosa
/
Genetics
/
Metabolism
/
Neovascularization, Pathologic
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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