Treatment of recurrent malignant brain gliomas by surgical excision combined with biodegradable polymers of interstitial chemotherapy / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 58-61, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-271036
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effectiveness of treatment of recurrent malignant brain gliomas by surgical excision combined with biodegradable polymers of interstitial chemotherapy.</p><p><b>METHODS</b>In 30 patients with recurrent malignant brain gliomas, the tumor was surgically removed and Vp-16 biodegradable polymers were implanted during operation in the tumor bed at a dose of 100 - 150 mg. The patients were followed up for 3 - 24 months, and the results were compared with 46 cases with the recurrent malignant brain gliomas who received operation only.</p><p><b>RESULTS</b>At 3, 6, 12, 24 months after treatment, the recurrent rate was 16.7%, 30%, 50% and 83.3%, respectively; the mortality rate was 6.67%, 20%, 40% and 70%, respectively. All the patients had no apparent side-effects of chemotherapy.</p><p><b>CONCLUSION</b>Surgical treatment combined with interstitial chemotherapy with biodegradable Vp-16 polymers improves the treatment result of recurrent malignant brain gliomas compared to surgery alone.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymers
/
Therapeutics
/
Brain Neoplasms
/
Mortality
/
Combined Modality Therapy
/
Etoposide
/
Glioma
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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