Relation between vascular endothelial growth factor and reoccurence-metastasis after transcatheter arterial chemoembolization in hepatocellar carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 562-565, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-271080
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relation between changes in serum vascular endothelial growth factor (VEGF) level after transcatheter arterial chemoembolization (TACE) and hepatocellular carcinoma (HCC) progression, especially in relation to metastasis.</p><p><b>METHODS</b>Serum VEGF expression level, measured by quatitative sandwich enzyme-linked immunosorbent assay (ELISA, R&D system), was measured before, 3 days and 4 weeks after TACE in 30 patients with HCC. The development of metastasis was evaluated at the end of the third month after TACE.</p><p><b>RESULTS</b>1. The serum VEGF level in 30 patients was 154.47 +/- 90.17 pg/ml, 2. Post-TACE total serum VEGF level increased as compared with their basal level in 30 patients (P < 0.05) and serum VEGF level had a tendency to increase in patients with heterogeneous uptake of iodized oil and portal vein thrombosis. During the follow-up of 1 - 2 years, metastatic foci were found in 74% (20) patients with SVEGF increase, while none of the patients showing SVEGF decrease developed metastasis.</p><p><b>CONCLUSION</b>Serum VEGF expression increase is associated with the development of metastasis in hepatocellular carcinoma after TACE.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Blood
/
Chemoembolization, Therapeutic
/
Carcinoma, Hepatocellular
/
Vascular Endothelial Growth Factor A
/
Liver Neoplasms
/
Neoplasm Metastasis
/
Neoplasm Recurrence, Local
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2003
Type:
Article
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