The role of the expression of PPAR-gamma gene in the adipogenesis in hemangioma evolution / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 45-48, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-271244
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of the expression of PPAR-gamma gene in the adipogenesis in hemangioma evolution.</p><p><b>METHODS</b>Routine immunohistochemistry staining of Perilipin A, the marker antigen of adipocytes, was performed to observe the adipogenesis in hemangioma. Immunofluorescence staining of PPAR-gamma, the important transcription factor in promoting adipogenesis, was carried out to observe its location in hemangioma tissue, with the co-staining of alpha-SMA and CD31. And RT-PCR was used to examine the expression of PPAR-gamma gene in hemangioma in different stages.</p><p><b>RESULTS</b>In the evolution of hemangioma, the number of adipocytes increased continuously. And the tumor was replaced by fibrofatty tissue finally. PPAR-gamma was located in the nuclei of perivascular cell in hemangioma tissue. The expression of PPAR-gamma gene in hemangioma increased in the evolution of hemangioma, but still was lower than that in normal fat tissue from children.</p><p><b>CONCLUSION</b>The expression of PPAR-gamma in the perivascular cells suggests that they may contribute to the adipogenesis in hemangioma involution.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Adipose Tissue
/
PPAR gamma
/
Adipogenesis
/
Hemangioma
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2013
Type:
Article
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