Preparation of gelatin nanogel modified with fluoride anion and its ultrasonic triggered release characteristics / 药学学报
Acta Pharmaceutica Sinica
;
(12): 313-317, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-271436
ABSTRACT
<p><b>AIM</b>To investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion.</p><p><b>METHODS</b>Adriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device.</p><p><b>RESULTS</b>The average diameter of ADM-FMNG was (46 +/- 12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g x L(-1), respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 degrees C. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W x cm(-2) of power density and 7-8 min duration, 51. 5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46 +/- 12) nm to (1,212 +/- 35) nm and restored after ultrasound stopped for 3-4 min.</p><p><b>CONCLUSION</b>ADM-FDNG system has the sensitive ultrasound triggered release characteristics.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Polyethylene Glycols
/
Polyethyleneimine
/
Ultrasonics
/
Drug Carriers
/
Doxorubicin
/
Chemistry
/
Drug Delivery Systems
/
Nanoparticles
/
Fluorides
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
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