Design, synthesis and insulin-sensitizing activity of indole derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 225-229, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-271471
ABSTRACT
<p><b>AIM</b>To design and synthesize compounds with insulin-sensitizing activity.</p><p><b>METHODS</b>Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.</p><p><b>RESULTS</b>One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.</p><p><b>CONCLUSION</b>This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Triglycerides
/
Drug Design
/
Adipocytes
/
3T3-L1 Cells
/
Hypoglycemic Agents
/
Indoles
/
Insulin
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
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