Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group / 药学学报
Acta Pharmaceutica Sinica
;
(12): 65-70, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-271483
ABSTRACT
<p><b>AIM</b>To search for new artemisinin derivatives with higher immunosuppressive activity.</p><p><b>METHODS</b>Two kinds of new artemisinin derivatives containing polyethylene glycol group were synthesized from dihydroartemisinin via condensation and esterification. These compounds were assayed for their inhibitory activity on ConA-induced T cell proliferation and LPS-induced B cell proliferation.</p><p><b>RESULTS</b>Twenty three new compounds (2a - 2f, 3a - 3d, 4a - 4f, 6a, 6b and 7a - 7g) were synthesized and identified by 1H NMR and elemental analysis.</p><p><b>CONCLUSION</b>These compounds had immunosuppressive activity in vitro. Among them, the symmetrical substituted compound 2 and 6 had higher activity than mono-substituted compound 3, 4 and 7. Especially, compounds 2a - 2f remarkably exhibited higher inhibition in comparison with artemisinin and artesunate.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polyethylene Glycols
/
Sesquiterpenes
/
B-Lymphocytes
/
T-Lymphocytes
/
Molecular Structure
/
Artemisinins
/
Cell Proliferation
/
Immunosuppressive Agents
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
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