Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.</p><p><b>METHODS</b>Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.</p><p><b>RESULT</b>BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).</p><p><b>CONCLUSION</b>Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.</p>