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Inherited mutations of MUTYH and colorectal cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 406-411, 2007.
Article in Chinese | WPRIM | ID: wpr-271512
ABSTRACT
MUTYH, one of base-excision repair enzymes, is associated with human genetic disorders. Inherited biallelic mutations in the human MUTYH gene are responsible for an autosomal recessive syndrome-adenomatous colorectal polyposis (MUTYH associated polyposis, MAP), which significantly increases the risk of colorectal cancer (CRC). In this article we review the relationship between BER and the oxidative damage to DNA, the functional overlap of BER with other repair proteins, the molecular mechanism of tumourigenesis in MAP, and delineate the MUTYH polyposis phenotype and its prevention.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA Damage / Colorectal Neoplasms / Risk Factors / Germ-Line Mutation / Adenomatous Polyposis Coli / DNA Glycosylases / Genetics / Mutation Type of study: Etiology study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA Damage / Colorectal Neoplasms / Risk Factors / Germ-Line Mutation / Adenomatous Polyposis Coli / DNA Glycosylases / Genetics / Mutation Type of study: Etiology study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2007 Type: Article