Expression of PDGFR-alpha in gastrointestinal stromal tumor and its clinical significance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 280-284, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-271535
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and clinical significance of platelet-derived growth factor receptor alpha (PDGFR-alpha) in gastrointestinal stromal tumor (GIST).</p><p><b>METHODS</b>Paraffin embedded tissue specimens from 119 GISTs were analyzed for PDGFR-alpha expression by immunohistochemical method, and specimens from non-GISTs were used as controls. Positive signals were shown in cytoplasma and cell membrane.</p><p><b>RESULTS</b>Of 119 GISTs,78 (65.5%) were positive for PDGFR-alpha . The expression rate of PDGFR-alpha protein in very low risk, low risk, intermediate risk and high risk cases was 52.9 % (9/17), 71.0% ( 22/31), 67.9% (19/28) and 65.1% (28/43), respectively (P>0.05). PDGFR-alpha protein expression rate was significantly different between GISTs and non-GISTs (P<0.05).</p><p><b>CONCLUSION</b>PDGFR-alpha combined with CD117 can be used in diagnosis and differential diagnosis of GIST, but it may not be used as a prognostic index.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Biomarkers, Tumor
/
Proto-Oncogene Proteins c-kit
/
Receptor, Platelet-Derived Growth Factor alpha
/
Gastrointestinal Stromal Tumors
/
Metabolism
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2007
Type:
Article
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