Research advances in human mitochondrial DNA with aging and degenerative diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 93-97, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-271569
ABSTRACT
The human mitochondrial genome consists of approximate 1500 genes, among which 37 are encoded by the mitochondrial DNA (mtDNA) and the remainder encoded in the nuclear DNA (nDNA). The mitochondria produces large amount of the cellular reactive oxygen species (ROS). ROS induces the mutations of mtDNA and mtDNA, which are associated with a wide range of age-related diseases including neurodegenerative diseases, cardiomyopathy, diabetes and various cancers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Aging
/
DNA, Mitochondrial
/
Genetic Therapy
/
Reactive Oxygen Species
/
Neurodegenerative Diseases
/
Genetics
/
Metabolism
/
Mitochondria
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2007
Type:
Article
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