Effects of basic fibroblast growth factor on bone marrow mesenchymal stem cell differentiation into temporomandibular joint disc cells / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 732-736, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-271699
ABSTRACT
The present paper is aimed to observe the effects of basic fibroblast growth factor (bFGF) on bone marrow mesenchymal stem cell (BMSCs) differentiation. The bFGF was used to stimulate BMSCs and histology, immunohistochemistry and enzyme linked immunosorbent assay (ELISA) were used to examine the extracellular matrix produced by induced BMSCs, evaluated the feasibility of BMSCs being the seeding cells of temporomandibular joint (TMJ) disc tissue engineering. The results showed that having been induced with bFGF, the BMSCs could differentiate into fibroblast-like cells, which could synthesize GAG and collagen type I matrix. So it is feasible for BMSCs as seeding cells for engineered TMJ disc.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Bone Marrow Cells
/
Goats
/
Cell Differentiation
/
Cells, Cultured
/
Fibroblast Growth Factor 2
/
Temporomandibular Joint Disc
/
Cell Biology
/
Collagen Type I
/
Tissue Engineering
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2012
Type:
Article
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