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Tail-suspended model simulating mouse oocytes maturation inhibited with microgravity / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 687-696, 2012.
Article in Chinese | WPRIM | ID: wpr-271708
ABSTRACT
We studied the effects of simulated microgravity on mouse oocytes maturation, and analyzed whether the tail-suspended model can be applied to investigate simulated microgravity effects on reproductive processes in female mice. Mouse oocytes were cultured in vitro with microgravity simulated by a rotating wall vessel bioreactor and by tail-suspended model, and the maturation rate of the mouse oocytes in the two models were examined in vivo. The maturation rate of mouse oocytes cultured in simulated microgravity was 8.93%, and that was 72.33% in 1g gravity. In ratio, oocyte maturation rate had no significant difference between the rotational group and control group. Microgravity simulated by the tail-suspended model inhibited mouse oocytes maturation and increased the rate of oocytes abnormity. The maturation rate of tail-suspended mouse oocytes was 14.54%, which was significantly lower than that of control group. Tail-suspended model should be an ideal model to investigate simulated microgravity effects on reproductive processes of female mice.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Oocytes / Oogenesis / Physiology / Cells, Cultured / Weightlessness Simulation / Hindlimb Suspension / Cell Biology Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oocytes / Oogenesis / Physiology / Cells, Cultured / Weightlessness Simulation / Hindlimb Suspension / Cell Biology Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2012 Type: Article