Progress in research on molecular biology and application in dominant antigens ESAT6 and CFP10 of TB vaccine / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 392-396, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-271767
ABSTRACT
As the dominant antigens, early secreted antigenic target 6 (ESAT6, E6) and culture filtrate protein 10 (CFP10, C10) had once been the focus of tuberculosis (TB) vaccine due to their capability of inducing strong cell immune response in the host. They are also endowed with promising future of prevention against and diagnosis of TB. In this review, we systematically introduce recent research progress of E6 and C10, especially in structure-function, biological characteristics, protein expression and secretion, host immunity and vaccine development, and the prospects of their application are also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Bacterial Proteins
/
Chemistry
/
Immunodominant Epitopes
/
Vaccines, DNA
/
Tuberculosis Vaccines
/
Allergy and Immunology
/
Genetics
/
Molecular Biology
/
Antigens, Bacterial
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2012
Type:
Article
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