Effect of gufuhuotang on hemorheology and lipid metabolism of hormonal necrosis of femoral head / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 769-771, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-271818
ABSTRACT
<p><b>OBJECTIVE</b>To probe the of Gufuhuotang effect on hemorheology and lipid metabolism of hormonal necrosis of femoral head.</p><p><b>METHOD</b>32 male rabbits of New Zealand were divided at random into pathological pattern group, normal control group, low-dosage of Gufuhuotang group and high-dosage group; models of osteocyte necrosis of head of femur were made with intragluteal injection of hydroprednisone acetate; the rabbits were observed weekly and killed 6 weeks later and HE pathological section was made to observe hemorheology index and blood-liquid content, and then analysis and comparison were made.</p><p><b>RESULT</b>Gufuhuotang could obviously decrease total blood low-shear viscosity, plasma viscosity, hemacocrit, serum cholesterol and triglyceride contents; under light microscope empty bone lacunas of femoral head were less, fat cells of medullary cavity were less and relatively small, and bone trabecula was sparse with no break.</p><p><b>CONCLUSION</b>Gufuhuotang has a distinct preventive and curative effect on rabbits' hormonal necrosis of femoral head.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Blood
/
Prednisone
/
Drugs, Chinese Herbal
/
Random Allocation
/
Chemistry
/
Hemorheology
/
Therapeutic Uses
/
Drug Combinations
/
Femur Head Necrosis
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2002
Type:
Article
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