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Study on improvement of dissolution rate of water-honeyed pills of six herbs with rehmunnia by technique of super fine crushing / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 511-513, 2002.
Article in Chinese | WPRIM | ID: wpr-271857
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the affection of crushing technology on quality. The dissolution of Pills of Six Herbs with Rehmunnia prepared by different crushing technology was determined by taking the dissolution of Paeonol as test marker.</p><p><b>METHOD</b>The Pills was prepared with the fine powder which was crushed by normal crusher or super fine crusher. The rotatory-basket method was used, and the cumulative dissolution percentage was determined by UV.</p><p><b>RESULT</b>Statistics indicated there was a significant difference in dissolution parameter (T50) between super fine crushing powder Pills and normal fine-crushing powder Pills (P < 0.01), and there was a difference in dissolution of different batches of Pills of Six Herbs with Rehmunnia prepared by the normal crush technique (P < 0.05).</p><p><b>CONCLUSION</b>The determination of dissolution of Pills of Six Herbs with Rehmunnia is necessary. In order to improve the quality of drugs, we should adopt the technique of super fine crushing in the preparation procedure.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Acetophenones / Plants, Medicinal / Quality Control / Solubility / Drugs, Chinese Herbal / Chemistry / Technology, Pharmaceutical / Rehmannia / Drug Combinations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Acetophenones / Plants, Medicinal / Quality Control / Solubility / Drugs, Chinese Herbal / Chemistry / Technology, Pharmaceutical / Rehmannia / Drug Combinations Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2002 Type: Article